Like other phenanthrene derivatives, dihydrocodeine is principally metabolised in the liver with the resultant metabolites getting excreted mainly from the urine.

Việc sử dụng đồng thời opioid với thuốc an thần như benzodiazepin hoặc các loại thuốc tương tự tăng nguy cơ an thần, ức chế hô hấp, hôn mê và tử vong do tác dụng ức chế thần kinh trung ương gia tăng.

The information under refers to products available in the United States that contain dihydrocodeine.

If you have any side effects, speak to your health care provider or pharmacist This contains any possible side effects not listed Within this leaflet. See section 4.

Drug Interactions Although selected medicines really should not be employed alongside one another in any respect, in other conditions two different medicines could be utilised alongside one another although an interaction could manifest. In these conditions, your physician should want to alter the dose, or other safeguards may very well be needed.

This medicine can impair cognitive function and might affect a patient’s capacity to drive safely. This class of medicine is in the list of drugs included in rules below 5a of the Road Site visitors Act 1988. When prescribing this medicine, patients ought to be explained to:

▪ Be sure to note that it's still an offence to drive Should you be unfit because read more of the medicine (i.e. your power to drive is currently being affected).” Facts with regards to a brand new driving offence regarding driving soon after drugs have been taken in britain could be discovered listed here:

Dihydrocodeine is available in Japan as tablets which contain 2.five mg of dihydrocodeine phosphate and caffeine, the decongestant d,l-methylephedrine HCl, as well as antihistamine chlorpheniramine, and packets of granules which effervesce like Alka-Seltzer with 10 mg of dihydrocodeine with lysozyme and chlorpheniramine, marketed for OTC sale as New Bron Solution-ACE.

During pregnancy, this medication must be utilized only when Obviously wanted. It may well hurt an unborn baby. Go over the risks and benefits with your medical doctor.

Nervous process side effects of chlorpheniramine have provided drowsiness in 75% or maybe more of treated patients. Dyskinesias have seldom been reported subsequent chronic use of chlorpheniramine.

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Hyperalgesia Hyperalgesia may very well be diagnosed When the patient on long-term opioid therapy presents with increased pain. This is likely to be qualitatively and anatomically unique from pain connected with disease development or to breakthrough pain resulting from advancement of opioid tolerance.

Previous to beginning treatment with opioids, a discussion needs to be held with patients to put in position a strategy for ending treatment with dihydrocodeine in order to minimise the risk of addiction and drug withdrawal syndrome (see section four.four).

But don't take ibuprofen with very similar painkillers like aspirin or naproxen without conversing with a pharmacist or doctor.